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| Registros recuperados : 18 | |
| 1. |  | CESAR, A. S. M.; REGITANO, L. C. de A.; LANNA, D. P. D.; POLETI, M. D.; KOLTES, J. E.; REECY, J. M.; FRITZ-WATERS, E.; KRAMER, L.; GARRICK, D.; MUDADU, M. de A.; TULLIO, R. R.; COUTINHO, L. L. Expression quantitative trait loci (eQTL) hotspot regions from whole genome analysis of Nellore steers. In: PLANT AND ANIMAL GENOME CONFERENCE, 24., 2016, San Diego. Anais... San Diego: PAG, 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 2. | | GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 3. | | OLIVEIRA, G. B.; REGITANO, L. C. de A.; CESAR, A. S. M.; REECY, J. M.; DEGAKI, K. Y.; POLETI, M. D.; FELICIO, A. M.; KOLTES, J. E.; COUTINHO, L. L. Integrative analysis of microRNAs and mRNAs revealed regulation of composition and metabolism in Nelore cattle. BMC Genomics, v. 19, n. 126, p. 2-16, 2018.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 4. | | ROCHA, M. I. P.; SOUZA, M. M. de; DINIZ, W. J. S.; LIMA, A. O. de; AFONSO, J.; TIZIOTO, P. C.; OLIVEIRA, P. N. de; REGITANO, L. C. de A.; KOLTES, J. E.; NICIURA, S. C. M. Liver DNA methylation profile in Nelore cattle extremes for feed efficiency. In: WORKSHOP DO PROGRAMA DE PÓS-GRADUAÇÃO EM GENÉTICA EVOLUTIVA E BIOLOGIA MOLECULAR, 1., 2019, São Carlos, SP. Anais... São Carlos: UFSCAR, 2019. p.64| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 5. | | CESAR, A. S. M.; REGITANO, L. C. de A.; KOLTES, J.; FRITZ-WATERS, E. R.; TULLIO, R. R.; LANNA, D. P. D.; REECY, J. M.; MOURÃO, G. B.; GASPARIN, G.; COUTINHO, L. L. Transcriptome profile in Longissimus dorsi muscle from Nellore steers with extreme GEBV for intramuscular fat percentage. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.07.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 6. | | PETRY, B.; MOREIRA, G. C. M.; COPOLA, A. G. L.; SOUZA, M. M. de; VEIGA, F. C. da; JORGE, E. C.; PEIXOTO, J. de O.; LEDUR, M. C.; KOLTES, J. E.; COUTINHO, L. L. SAP30 gene is a probable regulator of muscle hypertrophy in chickens. Frontiers in Genetic, v. 12, n. 709937, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. Frontiers in Genetics, v. 10, p. 1-14, July 2019. Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 8. | | CESAR, A. S. M.; REGITANO, L. C. de A.; REECY, J. M.; POLETI, M. D.; OLIVEIRA, P. S. N. de; OLIVEIRA, G. B. de; MOREIRA, G. C. M.; MUDADU, M. de A.; TIZIOTO, P. L.; KOLTES, J. E.; Fritz-Waters, E.; KRAMER, L.; GARRICK, D.; BEIKI, H.; GEISTLINGER, L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L. Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits. BMC Genomics, v. 19, p. 1-20, 2018. Article number: 499. Na publicação: Luciana C. A. Regitano, Maurício A. Mudadu, Adhemar Zerlotini.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 9. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; WATERS, E. F.; REECY, J. M.; COUTINHO, L. L. Association of skeletal muscle transcripts with fatty acid content in Nellore cattle. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 35., 2016, Salt Lake City. Proceedings... Salt Lake City: ISAG, 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 10. | | LUNNEY, J.; ROWLAND, B.; TRIBLE, B.; CHOI, I.; ABRAMS, S.; SOUZA, C.; REECY, J.; FRITZ-WATER, E.; KOLTES, J.; EISLEY, C.; TUGGLE, C.; HESS, A.; DUNKELBERGER, J.; DEKKERS, J.; BODDICKER, N.; STEIBEL, J.; ERNST, C.; GUAN, L. L.; BAO, H.; KOMMADATH, A.; STOTHARD, P.; PLASTOW, G.; LADINIG, A.; HARDING, J. C. S. Exploring genetic control of swine responses to viral diseases. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 34., 2014, 3., 2012, Xi'an, China. Abstract. Xi'an: ISAG, 2014. p. 5.| Biblioteca(s): Embrapa Pesca e Aquicultura. |
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| 11. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; FRITZ-WATERS, E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, London, v. 17, p. 1-16, 2016.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 12. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; FELICIO, A. M.; NASCIMENTO, M. L. do; CHAVES, A. S.; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; WATERS, E. F.; MOURAO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; COUTINHO, L. L. Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content. BMC Genomics, v. 17, n. 961, p. 1-16, 2016.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | ANDRADE, B. G. N.; DONATONI, F. A. B.; CUADRAT, R. R. C.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; KOLTES, J. E.; WALSH, P.; BERNDT, A.; PALHARES, J. C. P.; REGITANO, L. C. de A. The structure of microbial populations in Nelore GIT reveals inter-dependency of methanogens in feces and rumen. Journal of Animal Science and Biotechnology, v.11, n. 6, 2020. 10 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 14. | | ANDRADE, B. G. N.; DONATONI, F. A. B.; CUADRAT, R. R.; CARDOSO, T. F.; MALHEIROS, J. M.; OLIVEIRA, P. S. N. DE; PETRINI, J.; MOURÃO, G. B.; COUTINHO, L. L.; REECY, J. M.; KOLTES, J. E.; ZERLOTINI NETO, A.; MEDEIROS, S. R. de; BERNDT, A.; PALHARES, J. C. P.; AFLI, H.; REGITANO, L. C. de A. Stool and ruminal microbiome components associated with methane emission and feed efficiency in Nelore beef cattle. Frontiers in Genetics, v. 13, 812828, may, 2022. 12 p.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 15. | | SOUZA, M. M. de; NICIURA, S. C. M.; ROCHA, M. I. P.; PAN, Z.; ZHOU, H.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; AFONSO, J.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; KOLTES, J. E.; REGITANO, L. C. de A. DNA methylation may affect beef tenderness through signal transduction in Bos indicus. Epigenetics & Chromatin, v. 15, n. 1, p. 1-16, 2022. Article number: 15.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 16. | | LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. Frontiers in Genetics, v. 11, p. 1-14, Mar. 2020. Article 189. Na publicação: Luciana C. A. Regitano.| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 17. | | FINALLI, S. L.; SILVA, B. P. M. DA; GOMES, J. D.; ALMEIDA, V. V. DE; FREITAS, F. A. O.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J.; KOLTES, J.; KOLTES, D.; REGITANO, L. C. de A.; GARRICK, D. J.; BALIEIRO, J. C. DE C.; MEIRA, A. N.; FREITAS, L.; COUTINHO, L. L.; FUKUMASU, H.; MOURÃO, G. B.; ALENCAR, S. M. DE; LUCHIARI FILHO, A.; CESAR, A. S. M. Differential gene expression associated with soybean oil level in the diet of pigs. Animals, v. 12, n. 13 1632, jun. 2022. 21 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 18. | | FANALLI, S. L.; SILVA, B. P. M. DA; GOMES, J. D.; CICONELLO, F. N.; ALMEIDA, V. V. DE; FREITAS, F. A. O.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J.; KOLTES, J.; KOLTES, D.; REGITANO, L. C. de A.; BAILEIRO, J. C. DE C.; FREITAS, L.; COUTINHO, L. L.; FUKUMASU, H.; ALENCAR, S. M. DE; LUCHIARI FILHO, A.; CESAR, A. S. M. Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases. Scientific Reports, v. 12, 10318, jun. 2022. 10 p.| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 18 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
19/02/2019 |
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Data da última atualização: |
19/02/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
GONÇALVES, T. M.; REGITANO, L. C. de A.; KOLTES, J. E.; CESAR, A. S. M.; ANDRADE, S. C. da S.; MOURAO, G. B.; GASPARIN, G.; MOREIRA, G. C. M.; FRITZ-WATERS, E.; REECY, J. M.; COUTINHO, L. L. |
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Afiliação: |
Tássia Mangetti Gonçalves, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; James E. Koltes, Iowa State University; Aline Silva Mello Cesar, USP; Sónia Cristina da Silva Andrade, USP; Gerson Barreto Mourão, USP; Gustavo Gasparin, USP; Gabriel Costa Monteiro Moreira, USP; Elyn Fritz-Waters, Iowa State University; James M. Reecy, Iowa State University; Luiz Lehmann Coutinho, USP. |
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Título: |
Gene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Frontiers in Genetics, v.9, n. 441, p. 1-18, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Beef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptosis. PIF analysis identified myoglobin (MB), enolase 3 (ENO3), and carbonic anhydrase 3 (CA3) as potentially having fundamental roles in tenderness. Pathways identified in our study impacted in beef tenderness included: calcium signaling, apoptosis, and proteolysis. These findings underscore some of the complex molecular mechanisms that control beef tenderness in Nellore cattle. MenosBeef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptos... Mostrar Tudo |
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Palavras-Chave: |
Maciez da carne; Qualidade da carne. |
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Thesagro: |
Carne; Gado de Corte. |
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Thesaurus NAL: |
Beef; Beef cattle; Beef quality. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/193047/1/8-GeneCo-expressionAnalysis.pdf
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Marc: |
LEADER 02810naa a2200325 a 4500
001 2106256
005 2019-02-19
008 2018 bl uuuu u00u1 u #d
100 1 $aGONÇALVES, T. M.
245 $aGene co-expression analysis indicates potential pathways and regulators of beef tenderness in Nellore cattle.$h[electronic resource]
260 $c2018
520 $aBeef tenderness, a complex trait affected by many factors, is economically important to beef quality, industry, and consumer?s palatability. In this study, RNA-Seq was used in network analysis to better understand the biological processes that lead to differences in beef tenderness. Skeletal muscle transcriptional profiles from 24 Nellore steers, selected by extreme estimated breeding values (EBVs) for shear force after 14 days of aging, were analyzed and 22 differentially expressed transcripts were identified. Among these were genes encoding ribosomal proteins, glutathione transporter ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), and synaptotagmin IV (SYT4). Complementary co-expression analyses using Partial Correlation with Information Theory (PCIT), Phenotypic Impact Factor (PIF) and the Regulatory Impact Factor (RIF) methods identified candidate regulators and related pathways. The PCIT analysis identified ubiquitin specific peptidase 2 (USP2), growth factor receptor-bound protein 10 (GBR10), anoctamin 1 (ANO1), and transmembrane BAX inhibitor motif containing 4 (TMBIM4) as the most differentially hubbed (DH) transcripts. The transcripts that had a significant correlation with USP2, GBR10, ANO1, and TMBIM4 enriched for proteasome KEGG pathway. RIF analysis identified microRNAs as candidate regulators of variation in tenderness, including bta-mir-133a-2 and bta-mir-22. Both microRNAs have target genes present in the calcium signaling pathway and apoptosis. PIF analysis identified myoglobin (MB), enolase 3 (ENO3), and carbonic anhydrase 3 (CA3) as potentially having fundamental roles in tenderness. Pathways identified in our study impacted in beef tenderness included: calcium signaling, apoptosis, and proteolysis. These findings underscore some of the complex molecular mechanisms that control beef tenderness in Nellore cattle.
650 $aBeef
650 $aBeef cattle
650 $aBeef quality
650 $aCarne
650 $aGado de Corte
653 $aMaciez da carne
653 $aQualidade da carne
700 1 $aREGITANO, L. C. de A.
700 1 $aKOLTES, J. E.
700 1 $aCESAR, A. S. M.
700 1 $aANDRADE, S. C. da S.
700 1 $aMOURAO, G. B.
700 1 $aGASPARIN, G.
700 1 $aMOREIRA, G. C. M.
700 1 $aFRITZ-WATERS, E.
700 1 $aREECY, J. M.
700 1 $aCOUTINHO, L. L.
773 $tFrontiers in Genetics$gv.9, n. 441, p. 1-18, 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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